Tıp Fakültesi

Akademik Kadro

Prof. Dr. Engin  Ulukaya

Prof. Dr.
Engin Ulukaya

Tıbbi Biyokimya

Prof. Dr. Engin Ulukaya, 1987 yılında mezun olduğu İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesini takiben Uludağ Üniversitesinde Tıbbi Biyokimya uzmanlığını bitirmiştir. University of Leeds (UK), School of Biochemistry and Molecular Biology’de doktora (PhD) eğitimini tamamlamıştır. Temel kanser araştırmaları, hücre ölümü, kanser ilaç geliştirme, ve kişiye yönelik onkoloji alanlarında çalışmalar yapmaktadır. Moleküler kanser araştırma derneği (MOKAD) başkanlığının yanısıra, EACR (European Association for Cancer Research)’de Konsey Üyesi ve EORTC PathoBiology alt grubu asil üyesidir. Uluslararası dergilerde 137 makale yayınlamıştır (Google Scholar H index: 32, Atıf sayısı: 3385). 2003 yılında Güney Kore’de düzenlenen dünya patoloji ve laboratuvar tıbbı derneği (WASPALM) kongresinde “gelecek vaat eden laboratuvar hekimi” ödülünü almış ve WASPALM madalyasına hak kazanmıştır. Ayrıca 3’ü yurt dışı, 32 adet çeşitli kategorilerde ödülü bulunmaktadır. İstinye Üniversitesi Sağlık Bilimleri Dekanlığı görevini yürütmektedir. Ayrıca aynı üniversitenin Moleküler Kanser Uygulama ve Araştırma Merkezi (İSÜMKAM) Direktörüdür.

Araştırma Alanları

  • Kişiselleştirilmiş Onkoloji
  • Kanser Kök Hücre
  • Hücre Ölümü

Çalışma Alanları

  • Sağlık Bilimleri Temel Alanı
  • Tıbbi Biyokimya
  • The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation, 2022
  • Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans, 2022
  • Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis, 2022
  • Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy, 2022
  • DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives, 2022
  • Synthesis, DNA Binding and Cytotoxic Activity of Newcopper(II) Complexes of Trisubstituted Imidazoles, 2022
  • Novel 5-fluorouracil complexes of Zn(II) with pyridine-based ligands as potential anticancer agents, 2022
  • Pyruvate Dehydrogenase Contributes to Drug Resistance of Lung Cancer Cells Through Epithelial Mesenchymal Transition, 2022
  • Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells, 2022
  • Effects of Exosomes on Major Pathways Promote Tumor Formation and Progression, 2022
  • Preparation and Characterization of Palladium Derivate-Loaded Micelle Formulation in Vitro as an Innovative Therapy Option against Non-Small Cell Lung Cancer Cells, 2021
  • Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells, 2021
  • Anticancer Potential of Albumin Bound Wnt/beta-Catenin Pathway Inhibitor Niclosamide in Breast Cancer Cells, 2021
  • Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies, 2021
  • Tumor Chemosensitivity Assays Are Helpful for Personalized Cytotoxic Treatments in Cancer Patients, 2021
  • Epigenetic modulators combination with chemotherapy in breast cancer cells, 2021
  • Soloxolone methyl, as a 18 beta H-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells, 2021
  • Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells, 2021
  • Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach, 2021
  • Investigation of the efficacy of paclitaxel on some miRNAs profiles in breast cancer stem cells, 2021
  • Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis, 2021
  • Etoposide Loaded SPION-PNIPAM Nanoparticles Improve thein vitroTherapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis, 2020
  • A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex, 2020
  • Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling, 2020
  • Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship, 2020
  • Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines, 2020
  • Cytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis, 2020
  • Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand, 2020
  • Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity, 2020
  • Lichens exerts on anti - proliferative effect on human breast and lung cancer cells through induction of apoptosis, 2019
  • Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines, 2019
  • Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes, 2019
  • Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines, 2019
  • Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines, 2019
  • Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation, 2019
  • Synthesis and investigation of cytotoxicity of New N- and S,S-substituted-1,4-Naphthoquinone (NQ) Derivatives on Selected Cancer Lines, 2019
  • A Novel 1,4-Naphtoquinone-Derived Compound Induces Mitochondria-Mediated Apoptotic Cell Death in Breast Cancer Cells, 2019
  • Development of near-infrared region luminescent N-acetyl-L cysteine-coated AgS quantum dots with differential therapeutic effect, 2019
  • A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer, 2018
  • Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage, 2018
  • Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells., 2018
  • Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)-2,2\u2032:6\u2032,2\u2033-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker, 2018
  • An Investigation of Anticancer Effects of Doxorubicin and Calcitriol Combination on MCF-7 Cells, 2018
  • Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA, 2018
  • An Investigation of Anticancer Effects of Doxorubicin and Calcitriol Combination on MCF-7 Cells, 2018
  • Chloroquine Used in Combination with Chemotherapy Synergistically Suppresses Growth and Angiogenesis In Vitro and In Vivo, 2018
  • Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells., 2018
  • Usnea filipendula Induces Apoptosis in Human ColonCancer Cell Lines, 2018
  • Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino)propane/butane: Synthesis, structure, antiproliferative activity and mechanism of action, 2018
  • Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA, 2018
  • Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells, 2018
  • Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells, 2018
  • Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA, 2018
  • Usnea filipendula Induces Apoptosis in Human Colon Cancer Cell Lines., 2018
  • CHLOROQUINE USED COMBINATION WITH CHEMOTHERAPY SYNERGISTICALLY SUPRESSES GROWTH AND ANGIOGENESIS IN VITRO AND IN VIVO, 2018
  • A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer, 2018
  • Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage., 2018
  • Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells, 2018
  • A PROMISING NATURAL PRODUCT PRISTIMERIN RESULTS IN CYTOTOXICITY AGAINST BREAST CANCER STEM CELLS IN VITRO AND XENOGRAFTS IN VIVO THROUGH APOPTOSIS AN INCOMPLETE AUTHOPHAGY IN BREAST CANCER, 2018
  • Folic acid-conjugated Cationic Ag2S Quantum Dots for Optical Imaging and Selective Doxorubicin Delivery to HeLa Cells, 2017
  • Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity, 2017
  • Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line, 2017
  • Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line., 2017
  • Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line, 2017
  • Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity, 2017
  • A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer, 2017
  • Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo, 2017
  • Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells, 2017
  • Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line, 2017
  • Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines, 2017
  • A trans platinum II complex induces apoptosis in cancer stem cells of breast cancer, 2017
  • Nonapoptotic cell death induced by Hypericum species on cancer cells, 2017
  • Nonapoptotic cell death induced by Hypericum species on cancer cells, 2017
  • Nonapoptotic cell death induced by Hypericum species oncancer cells, 2017
  • Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line, 2017
  • Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line, 2017
  • Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines, 2017
  • Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl) amine and terpyridine, 2017
  • The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine, 2017
  • A trans platinum II complex induces apoptosis in cancer stem cells of breast cancer, 2017
  • Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line, 2017
  • Synthesis biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents, 2017
  • A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model, 2017
  • Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells, 2017
  • Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells., 2017
  • Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II ), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine, 2017
  • Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells., 2017
  • Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity, 2017
  • Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo, 2017
  • The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts, 2017
  • Anti angiogenic effect of a Palladium II Saccharinate Complex of Terpyridine in vitro and in vivo, 2017
  • Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents, 2017
  • Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents, 2017
  • Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents, 2017
  • Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines, 2017
  • The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine, 2017
  • Validation data supporting the characterization of novel copper complexes as anticancer agents, 2016
  • Cytotoxic Effect of Conyza canadensis (L.) Cronquist on Human Lung Cancer Cell Lines, 2016
  • Apoptosis-inducing Effect of a Palladium(II) Complex-[PdCl(terpy)](sac).2H2O] on Ehrlich Ascites Carcinoma (EAC) in Mice., 2016
  • The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro, 2016
  • Olive leaf extract containing oleuropein modulates the cytotoxic effect of epirubicin on breast cancer cells depending on the cell line, 2016
  • Ni/Cu/Zn 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2′-dipyridylamine: synthesis, structures, DNA/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death, 2016
  • Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines., 2016
  • Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L. and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro: Involvement of DNA Damage, 2016
  • Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro, 2016
  • The levels of caspase cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival, 2016
  • The involvement of IL 10 IL 6 IFN gamma TNF alpha and TGF beta gene polymorphisms among Turkish lung cancer patients, 2016
  • The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested, 2016
  • Salivary Gland Tumors, 2015
  • Cancer of the Eye (Intraocular Cancer), 2015
  • Design, Synthesis, Biological Evaluation, and Antioxidant and Cytotoxic Activity of Heteroatom-Substituted 1,4-Naphtho- and Benzoquinones, 2015
  • Cationic Pd(II)/Pt(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine: Synthesis, structures,DNA/BSA interactions, intracellular distribution, cytotoxic activity and induction of apoptosis, 2015
  • Anti growth effect of a novel trans dichloridobis 2 2 hydroxyethyl pyridine platinum II complex via induction of apoptosis on breast cancer cell lines, 2015
  • Addition of niclosamide to palladium II saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer, 2015
  • In vitro antibacterial activity of sponge-associated fungi against bacterial aquaculture pathogens., 2015
  • The M30 assay does not detect apoptosis in epithelial derived cancer cells expressing low levels of cytokeratin 18, 2015
  • IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis, 2015
  • Cytotoxic activity of novel palladium-based compounds on leukemia cell lines, 2015
  • Anticancer effect of a novel palladium-saccharinate complex of terpyridine by inducing apoptosis on Ehrlich ascites carcinoma (EAC) in Balb-C mice., 2015
  • A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line, 2015
  • Promising anticancer activity of a lichen Parmelia sulcata Taylor against breast cancer cell lines and genotoxic effect on human lymphocytes, 2015
  • Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line, 2014
  • Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress, 2014
  • Cancer stem cells: emerging actors in both basic and clinical cancer research, 2014
  • Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro, 2014
  • Biochemical and Proteomic Analysis of a Potential Anticancer Agent: Palladium(II) Saccharinate Complex of Terpyridine Acting through Double Strand Break Formation, 2014
  • Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent, 2014
  • Genotoxic, cytotoxic, and apoptotic effects of crude extract of Usnea filipendula Stirt. in vitro, 2014
  • Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo, 2014
  • Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells, 2014
  • Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells, 2014
  • Isolation of Major Phenolic Compounds from the Extracts of Prunella L. Species Grown in Turkey and Their Antioxidant and Cytotoxic Activities, 2014
  • Can safe and long-term exposure to extremely low frequency (50 Hz) magnetic fields affect apoptosis, reproduction, and oxidative stress?, 2013
  • Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro, 2013
  • Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells, 2013
  • Palladium(II) saccharinate complexes with bis(2-pyridylmethyl)amine induce cell death by apoptosis in human breast cancer cells in vitro, 2013
  • Synthesis structural characterization and cell death inducing effect of novel palladium II and platinum II saccharinate complexes with 2 hydroxymethyl pyridine and 2 2 hydroxyethyl pyridine on cancer cells in vitro, 2013
  • Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro, 2013
  • Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands, 2013
  • Changes in Gene Methylation Following Chemotherapyin Breast Cancer Cell Lines, 2013
  • trans Dichloridopalladium II and platinum II complexes with 2 hydroxymethyl pyridine and 2 2 hydroxyethyl pyridine Synthesis structural characterization DNA binding and in vitro cytotoxicity studies, 2013
  • Peripherally located A431 cells are more sensitive to cell death induced by exogenous oxidative stress., 2012
  • The p53 independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib, 2012
  • A glance at the methods for detection of apoptosis qualitatively and quantitatively, 2011
  • Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine, 2011
  • Chemotherapy increases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients, 2011
  • The Expressions of pAkt and PTEN in Lung Cancer Patients 24 Hours After the Cisplatin-Based Chemotherapy: A Prospective Pilot Study, 2011
  • Circulating Levels of Vascular Endothelial Growth Factor A and Its Soluble Receptor in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease, 2011
  • Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate, 2011
  • Toward a Biochemical Diagnosis of NASH: Insights From Pathophysiology For Distinguishing Simple Steatosis From Steatohepatitis, 2011
  • Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo, 2011
  • Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro, 2011
  • Apoptosis: why and how does it occur in biology?, 2011
  • Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease, 2010
  • Molecular signatures of nonalcoholic fatty liver disease: The present and future, 2010
  • Serum fetuin A/ 2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis, 2010
  • The ATP assay, but not the MTT assay, detects further cytotoxicity of the combination of anthracyline-based therapy with histone deacetylase inhibitor (Valproic acid) in breast cancer cells, 2010
  • Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain, 2010
  • Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation, 2010
  • sFas levels increase in response to cisplatin-based chemotherapy in lung cancer patients, 2010
  • Utilization of cytokeratin-based biomarkers for pharmacodynamic studies, 2010
  • Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetic patients., 2010
  • . Proteomic analysis of serum in patients with nonalcoholic steatohepatitis using MALDI-TOF/MS., 2009
  • Apoptosis-Inducing Effects of Morinda citrifolia L. (Noni) and Doxorubicin on the Ehrlich Ascites (EAC) Tumor in Balb-c Mice, 2009
  • Effect of Mobile Phone Exposure on Apoptotic Glial Cells and Status of Oxidative Stress in Rat Brain, 2009
  • Serial changes in circulating M30 antigen, a biomarker of apoptosis, in patients with acute coronary syndromes: relationship with the severity of coronary artery disease, 2009
  • Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance, 2009
  • Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C., 2009
  • Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease, 2009
  • The quest for liver fibrosis biomarkers: Promises from the enhanced liver fibrosis panel and beyond, 2009
  • Commentary on the study of Vos et al. "Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease, 2009
  • Serum M30 levels: A potential biomarker of severe liver disease in nonalcoholic fatty liver disease and normal aminotransferase levels, 2009
  • "A biomarker biopsy” for the diagnosis of NASH: promises from CK-18 fragments, 2008
  • Cytokine Gene Polymorphism and Postreperfusion Syndrome During Orthotopic Liver Transplantation, 2008
  • The Differential Anticancer Effects of Green Tea in Estrogen Receptor-Positive and Estrogen Receptor-Negative Human Breast Cancer Cell Lines., 2008
  • The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested., 2008
  • Mobile phone exposure does not induce apoptosis on spermatogenesis in rats, 2008
  • Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?, 2008
  • The involvement of IL-10, IL-6, IFN-gamma, TNF-alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients., 2008
  • VEGF, VEGF-receptors and lung cancer, 2007
  • Clinical significance of activity of ALT enzyme in patients with hepatitis C virus., 2007
  • Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is decreased in lung cancer patients showing progression: a pilot study., 2007
  • Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis., 2007
  • The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival., 2007
  • Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis, 2007
  • Higher serum nitrate levels are associated with poor survival in lung cancer patients., 2006
  • Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: a prospective pilot study., 2006
  • Investigation of fecal pancreatic elastase-1 levels in type 2 diabetic patients., 2005
  • Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women., 2005
  • Cytokine gene polymorphism and early graft rejection in liver transplant recipients., 2004
  • Evaluation of the effects of helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective, sixth-month follow-up study., 2004
  • Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay, 2004
  • Interference by Anti Cancer Chemotherapeutic Agents in the MTT Tumor Chemosensitivity Assay, 2004
  • Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation, 2003
  • 4-(N-Hydroxyphenyl)retinamide can Selectively Induces Apoptosis in Human Epidermoid Carcinoma Cells but not in Normal Dermal Fibroblasts., 2001
  • Fenretinide and Its Relation to Cancer, 1999
  • The effect of melatonin on lipid peroxidation during radiotherapy in female rats, 1999
  • General Practitioners' Opinions about the Basic Sciences in Relation to Medicine, 1995
  • Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells,
  • Özgün bir palladyum-barbitürat bileşiğinin anti-kanser ilaç adayı olarak preklinik analizi, 2017
  • Combination Therapy with Valproic Acid and Cu (II)- Barbiturate Complex Induces ROS-Mediated Apoptosis in Breast Cancer Stem Cell, 2018
  • Paklitaksel Tedavisinin Meme Kanseri Kanser Kök Hücrelerinde miRNA Ekspresyon Profiline Etkisi, 2018
  • Cytotoxic/Apoptotic effects of the benzofuran-substituted chalcone derivatives in colon cancer., 2017
  • Palladıum Incorporated Mıcelle: A Promısıng Materıal For Future Non-Small Cell Lung Cancer, 2017
  • Chloroquine improves the anticancer effectsof doxorubicin in vitro and in vivo models on Mouse Mammary Tumor Ehrlich ascites carcinoma (EAC), 2017
  • Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism, 2019
  • Cytotoxic Activites of 3-bromo-5-chloro-2-hydroxyacetophenone-N-phenyl-thiosemicarbazone and 3-bromo-5-chloro-2-hydroxy-acetophenone-N-phenylthiosemicarbazidato triphenylphosphine Nickel(II) Complex Against MCF-7 (Cancer), 2017
  • Thiosemicarbazone and Nickel(II) Complex Activites Against DU145 Cells, 2017
  • The cytotoxic activities of substitue-salicylaldehyde-S-methyl-thiosemicarbazone and it’s complex against MCF-7 cell line, 2017
  • N-Substituted Thiosemicarbazones - Synthesis,Characterization and Comparison of Cytotoxicities Against MCF 7 Cell, 2017
  • TARGETING BREAST CANCER STEM CELLS VIA DUALINHIBITION OF WNT SIGNALING AND HISTONE DEACETYLATION, 2018
  • Benzofuran İçeren Yeni Kalkon Bileşiklerinin Kolon Kanseri Üzerine olan Sitotoksik/Apoptotik Etkilerinin İncelenmesi, 2017
  • The Other Faces of Death: Cell Type Dependent Apoptotic Effects of Dinuclear Pd (II) Compound,
  • Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis,
  • Türkiye’de Yetişen Chrysophthalmum Schultz Bıp. Türleri Üzerinde Farmakognozik Araştırmalar, 2018
  • The anti-angiogenic effect of the Palladium(ll) Complex-[PdCI(terpy)](sac).2H20] on HUVECs tube formation and in vivo CAM assay, 2018
  • SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF SOME NEW MANNICH BASES DERIVED FROM 1,2,4-TRIAZOLES,
  • INVESTIGATION OF ANTI-CANCER ACTIVITY OF ADANSONIADIGITATA (BAOBAB) IN DIFFERENT CANCER CELLS, 2017
  • Cytotoxıc Effect of Dıfferent Extracts of Salvıa Candıdıssıma Vahl. Ssp.candıdıssıma on Lung Cancer Cells., 2017
  • Palladium Incorporated Micelle: A Promising Material for Future Non-Small Cell Lung Cancer., 2017
  • Palladium nanoparticles selectively ınduce apoptosis in lung cancer cells through reactive oxygen species., 2017
  • Pristimerin’in Meme Kanseri Hücreleri Üzerine in vitro ve in vivo Sitotoksik Etkisi,
  • N-Substituted Thiosemicarbazones-Synthesis, Characterization and Comparison of Cytotoxicities Against MCF 7 Cell, 2017
  • CYTOTOXIC EFFECT OF DIFFERENT EXTRACTS OF SALVIACANDIDISSIMA VAHL. SSP. CANDIDISSIMA ON LUNG CANCERCELLS, 2017
  • Chloroquine improves the anticancer effects of doxorubicin in vitro and in vivo models on Mouse Mammary Tumor Ehrlich ascites carcinoma (EAC), 2017
  • Investigation of Anti-Cancer Activity of Adansonia digitata (Baobab) In Different Cancer Cells., 2017
  • Reversal of Unresponsive Lung Cancer Cases Treated on the Basis of an Ex Vivo Tumor Chemosensitivity Assay (Onkogram®)., 2017
  • PALLADIUM INCORPORATED MICELLE: A PROMISING MATERIAL FOR FUTURE NON-SMALL CELL LUNG CANCER, 2017
  • Computer-Aided Prediction and Experimental Evaluation of Dithiocarbamates of 9,10-Anthracenedione as New Anticancer Agents, 2017
  • Mammospheres Cancer Stem Cell Enriched Population in Breast Cancer Show Resistance Against A Palladium II Saccharinate Complex of Terpyridine, 2015
  • Palladium II Based Novel Approach to Kill Cancer Stem Cells of Breast Cancer, 2015
  • Inhibition of sonic hedgehog pathway in breast cancer stem cells does not provide extra benefit in cytotoxicity resulted from Pd II saccharinate complex of terpyridine, 2015
  • Palladium II based anticancer compounds A new hope or an illusion, 2015
  • Moleküler Kanser Biyolojisi, ISBN: 9786052329306, 2018