Tıp Fakültesi

Akademik Kadro

Doç. Dr. Muradiye  Acar

Doç. Dr.
Muradiye Acar

Tıbbi Genetik

Lisans eğitimini Selçuk Üniversitesi Fen Fakültesi Biyoloji Bölümü’nde 2002 yılında bölüm ikincisi olarak tamamlayan Muradiye ACAR, yüksek Lisansını 2005 yılında, Doktorasını (PhD) 2012 yılında Selçuk Üniversitesi Tıbbi Genetik programında tamamlamıştır. 2011-2015 yılları arasında MIT tarafından düzenlenen iGEM (International genetically engineered machines) yarışmasından kazandığı 4 altın ve 1 gümüş madalyası bulunmaktadır. Dr. Acar’ın çok sayıda uluslararası yayını mevcuttur. Projelerde yürütücülük ve araştırmacılık yapmıştır. Tıbbi Genetik Derneği, MOKAD ve EACR üyesidir. Dr. Acar 2018 yılından itibaren İstinye Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı’nın akademik kadrosunda yer almaktadır.

Araştırma Alanları

  • Kanser Genetiği
  • Epigenetik
  • Kanser Kök Hücre
  • Sentetik biyoloji
  • Sitogenetik
  • Moleküler Genetik

Çalışma Alanları

  • Sağlık Bilimleri Temel Alanı
  • Tıbbi Genetik
  • Cancer stem cell isolation and characterization from lung cancer cells, 2023
  • Boric acid’s cytotoxic effect on CD133⁺ cancer stem cells in H460 cell line, 2023
  • Novel RUNX1 Variation in B-cell Acute Lymphoblastic Leukemia., 2023
  • Pankreas Kanseri Hücrelerinde Tripartite Motif-Containing Protein 3 (TRIM3) Gen Ekspresyonunun Araştırılması, 2022
  • Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea, 2019
  • Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis, 2018
  • Prevalence of human papilloma virus types in Turkish and Albanian women, 2018
  • Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells, 2018
  • A Novel Ganciclovir Resistance Mutation in the UL97 Gene of the HHV-5 in an Adult Hematopoietic Stem Cell Transplant Recipient, 2017
  • Investigation of the expression of RIF1 gene on head and neck, pancreatic and brain cancer and cancer stem cells, 2016
  • Association of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population, 2016
  • Investigation of the effects of 5-fluorouracil and thymoquinone on head and neck cancer stem cells, 2015
  • A comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC-UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines, 2015
  • Matrix Metalloproteinases 2 and 9 Polymorphism in Patients With Myeloproliferative Diseases A STROBE-Compliant Observational Study, 2015
  • The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease, 2015
  • Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?, 2015
  • Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1, 2015
  • Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation, 2015
  • The Role of ADAMTS9 Gene Promoter (Ca) Repeat in Developmental Hip Dysplasia, 2015
  • The effects of salidrosid on DIABLO and XAF1 gene expression in PC3 prostat cancer cells, 2014
  • The effect of survivin gene promoter polymorphism on breast cancer, 2014
  • Loss of heterozygosity in ING3 and ING5 genes in breast cancer, 2014
  • The role of human Dectin-1 Y238X gene polymorphism in recurrent vulvovaginal candidiasis infections, 2014
  • The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells, 2014
  • A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer, 2013
  • Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells, 2013
  • The Effects of Caffeic Acid Phenethyl Ester (CAPE), Royal Jelly, and Curcumin on Gene Expression of ADAMTS-1, -5, and -9 in OUMS-27 Chondrosarcoma Cells: A Preliminary Study, 2013
  • Analysis of promoter methylation of Dickkopf1 (DKK1) gene in breast cancer, 2012
  • HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls, 2012
  • Pelvik Organ Prolapsusu İle Doku Fibrillin-1 Seviyeleri Arasında İlişki Var Mı?, 2015
  • The Relationship Between Cytosine Adenine Repeat Polymorphism In The Promoter Regionofadamts9 A Distintegrinand Metalloproteinase With Thrombospondin Motif 9 Gene Andclinical And Radiologic Severity Of Knee Osteoarthritis, 2014
  • The Anti Cancer Activity Of Propolis In Colorectal Cancer, 2013
  • The effects of hypericin on p53 and ADAMTS gene expression inMCF 7 breast cancer cell line, 2014
  • Investigation of the Role of ING1 splice variants p24ING1 and p33ING1 in carcinogenesis and metastasis of head and neck cancer, 2014
  • Effect of boric acid on head and neck cancer cell lines, 2014
  • Effect of Survivin gene 1547 A G rs3764383 polymorphismin Turkish breast cancer patients, 2014
  • Mutation Analysis of ESM 1 Gene in Breast Cancer Patient Tissues, 2014
  • Overexpression of microRNAs May Be Key to Decreased Autophagy and PRR in the Pathogenesis of Focal Segmental Glomerulosclerosis, 2014
  • Identification and characterisation of pancreatic cancer stem cells, 2015
  • Evaluation of anti tumor effect of combined use of thymoquinonewith mitoxantrone in YKG1 glioma cells, 2015
  • Genetic association of 5 HT1A and 5 HT1B gene polymorphisms with OCD in the Turkish population, 2015
  • The development of a novel hypoxia inducible system to treat cardiovascular diseases caused by ischemia, 2016
  • The relationship between alcohol dependence and prodynorphin gene polymorphisms among Turkish men, 2014
  • Prodynorphin gene polymorphisms are not related with heroin dependency among Turkish men: a pilot study, 2014
  • The Effects Of Sali̇drosi̇d On Diablo And Xaf1 Gene Expressi̇on In Pc3 Prostate Cancer Cells, 2014
  • Link Between ADAMTS9 Aggrecanase Gene and Breast Cancer, 2012
  • Investigation of Microsatellite Instability in Colorectal Cancer Patients, 2023
  • Mutation Status of P53 in Head and Neck Squamous Cell Carcinoma,
  • The effects of caffeic acid phenethyl ester CAPE royal jelly and curcumin on gene expression of ADAMTS1 5 and 9 in OUMS 27 chondrosarcoma cells,
  • Examination Of Cell-Free DNA Mutations In Lung Cancer Patients By Next-Generation Sequencing Method,
  • Cytotoxıc Effect Of Boric Acid On Cancer Stem Cells In Lung Cancer,
  • Tarama Testinden Preimplantasyon Genetik Tanıya Doğru Sma Hastalığı: Önlenebilir Bir Halk Sağlığı Problemi Midir?,
  • IL 1 up regulates ADAMTS9 mRNA expression in cancer cells,
  • Ailesel Akdeniz Ateşi Fmf Tespit Edilen Olgularda Tlr 2 Tlr 4 Saa1 Gen Polimorfizmlerinin Amiloidozis Ve Kolşisin Direnci Gelişimi Üzerine Olan Etkisi,
  • Erkek İnfertilitesi İle Spermatogenez Gen Polimorfizmlerinin İlişkisi,
  • Glioma Kök Hücre İzolasyonu Ve Karakterizasyonu,
  • İnsan Kondrosit Ve Oums 27 Kondrosarkom Hücre Kültürlerinde Ankaferd Kullanımının Etkinliği,
  • The relationship between breast cancer and Tetraspanin8 TSPAN8 gene polymorphism,
  • Sıçan Epilepsi Modelinde Cep Telefonu Radyasyonu Maruziyetinin Scn1a Geni Üzerine Etkileri,
  • Gebeliğe Bağlı Oluşan Strialı Hastalarda Matriks Metalloproteinaz 2 Ve MatriksMetalloproteinaz 9 Polimorfizminin Analizi,
  • Tıp, Hemşirelik ve Sağlık Bilimlerine İnovatif Yaklaşımlar: Dinamikler ve Değişimler, ISBN: 978-975-447-614-9, 2023
  • Omics for Personalized Medicine, ISBN: 978-81-322-1184-6, 2013
  • Noninvasive Molecular Markers in Gynecologic Cancers, ISBN: 9781466569386, 2015
  • Omics Approaches in Breast Cancer - Towards nextgeneration diagnosis prognosis and therapy, ISBN: 978-81-322-0843-3, 2014
  • A Concise Review of Molecular Pathology of Breast Cancer, ISBN: 978-953-51-2030-8, 2015
  • Silver medal, 2015
  • Gold medal, 2014
  • Gold medal, 2013
  • Best natural biobrick, 2011
  • Gold Medal, 2011
  • Bronze Award, 2012
  • BÖLÜM İKİNCİLİĞİ, 2002