Faculty of Medicine

Academic Members

Özlem Büyüktanır Yaş

Özlem Büyüktanır Yaş,  Assoc. Prof.

Faculty Member

Dr. Özlem Büyüktanır Yaş completed her high school education in TED Ankara College in 1988 and her undergraduate education in Ankara University, Faculty of Science, Biology Department in 1992. Büyüktanır Yaş completed her PhD in Ankara University, Faculty of Veterinary Medicine, Department of Microbiology in 2003. She started serving in the Ministry of Health in 1994, Directorate General Primary Health Care Services, and then worked at Refik Saydam Hygiene Center, Vaccine Production, Research and Control Directorate in 1996-2004. She performed production of pertussis vaccine and control of diphtheria, pertussis and tetanus vaccines, and conducted research on vaccine development. In 1998, she conducted research on the development and control methods of the Cell Free Whooping Vaccine at the Food and Drug Administration (FDA / Food and Drug Administration) for 4 months. She was the chief of the Bacterial Vaccines Control and Research Laboratory within the Directorate. She worked as an assistant professor at Ondokuz Mayis University, Faculty of Veterinary Medicine, Department of Microbiology between 2004-2015. She gained the position of Associate Professor in 2015. Between 2013 and 2014, she conducted researches on the subject of "Development of new diagnostic tests for the diagnosis of Lyme Disease and Leptospirosis and development of effective vaccines for Lyme Disease" at the University of Maryland, USA for 1 year. Her research studies were basically on diagnosis of infectious diseases by conventional and molecular biological techniques, development of new, alternative molecular and serological diagnostic tests, development of new efficient vaccines. She is experienced on purification of the immuno-dominant antigens of the causative agents of the infections by chromatographic methods, cloning the targeted genes and production of recombinant proteins as vaccine candidates or development of sero-diagnostic tests based on these antigens. During this period, she worked as a director and researcher in 16 research grands, 6 of which were TÜBİTAK, DPT and KOSGEB grands. She is an international book editor and book chapter author, and has 2 national patents for the rapid diagnosis of infectious diseases. Dr. Büyüktanır Yaş has been in the academic staff of Istinye University, Department of Microbiology and Clinical Microbiology since 2018. She was the Head of the Department for 9 months beginning from March to the end of December 2019. She has collaborative studies with Professors from Maryland University and Yale University. Recently, she has been doing research on antimicrobial resistance.

Research Areas: Moleküler bakteriyoloji, enfeksiyon hastalıkları tanı testlerinin geliştirilmesi, aşı geliştirme

Main Areas: Veterinerlik Mikrobiyolojisi, 

GENÇ OKTAY,ÇETİNKOL YELİZ,BÜYÜKTANIR YAŞ ÖZLEM,YURDUSEV NEVZAT. (2019), Validation of Two Rapid Serological Tests for Human Brucellosis Detection, International Journal of Medical and Dental Sciences, 8(1), 1686-1692.
GENÇ OKTAY,SERDAR GÜLNUR,BÜYÜKTANIR YAŞ ÖZLEM,GENÇ EVRİM. (2019), Monitoring of the immune response to B. abortus S19 conjunctival vaccine in cattle, Ankara Universitesi Veteriner Fakultesi Dergisi, 66(1), 53-58.
Singh Preeti,Verma Deepshikha,Backstedt Brian T,Kaur Simarjot,Kumar Manish,Smith Alexis A,Sharma Kavita,Yang Xiuli,Azevedo José F,Gomes-Solecki Maria,BÜYÜKTANIR YAŞ ÖZLEM,Pal Utpal. (2017), Borrelia burgdorferi BBI39 Paralogs, Targets of Protective Immunity, Reduce Pathogen Persistence Either in Hosts or in the Vector, The Journal of Infectious Diseases, 215(6), 1000-1009.
AÇICI MUSTAFA,BÜYÜKTANIR YAŞ ÖZLEM,BÖLÜKBAŞ CENK SONER,PEKMEZCİ GÖKMEN ZAFER,GÜRLER ALİ TÜMAY,UMUR ŞİNASİ. (2017), Serologic detection of antibodies against Fasciola hepatica in sheep in the middle Black Sea region of Turkey, Journal of Microbiology, Immunology and Infection, 50(3), 377-381.
Yang Xiuli,Lin Yi Pin,Heselpoth Ryan D,BÜYÜKTANIR YAŞ ÖZLEM,Qin Jinhong,Kung Faith,Nelson Daniel C,Leong John M,Pal Utpal. (2016), Middle region of the Borrelia burgdorferi surface located protein 1 Lmp1 interacts with host chondroitin 6 sulfate and independently facilitates infection, Cellular Microbiology, 18(1), 97-110.
SMITH ALEXIS,NICHOLAS NAVASA,XIULI YANG,CARA N WILDER,BÜYÜKTANIR YAŞ ÖZLEM,MARQUES ADRIANA,ANGUITA JUAN,PAL UTPAL. (2016), Cross Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector, Cell Host & Microbe, 20(1), 91-98.
KUNG FAITH,KAUR SIMARJOT,SMITH ALEXIS A,YANG XIULI,WILDER CARA N,SHARMA KAVITA,BÜYÜKTANIR YAŞ ÖZLEM,PAL UTPAL. (2016), A Borrelia burgdorferi Surface Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target, Journal of Infectious Diseases, 213(11), 1786-1795.
YE MEIPING,SHARMA KAVITA,THAKUR MEGHNA,SMITH ALEXIS,BÜYÜKTANIR YAŞ ÖZLEM,XIANG XUWU,YANG XIULI,PROMNARES KAMOLTIP,LOU YONGLIANG. (2016), HtrA a Temperature and Stationary Phase Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant Facilitates Borrelia burgdorferi Infection in Mammalian Hosts, Infection and Immunity, 84(8), 2372-2381.
KARIU TORU,SHARMA KAVITA,SINGH PREETI,SMITH ALEXIS,BACKSTEDT BRIAN,BÜYÜKTANIR ÖZLEM,PAL UTPAL. (2015), BB0323 and Novel Virulence Determinant BB0238 Borrelia burgdorferi Proteins That Interact With and Stabilize Each Other and Are Critical for Infectivity, Journal of Infectious Diseases, 211(3), 462-471.
BACKSTEDT BRIAN,BÜYÜKTANIR ÖZLEM,LINDOW JANET,WUNDER ELSIO,MITERMAYER REİS,USMANI BROWN SAHAR,LEDIZET MICHEL,KO ALBERT,PAL UTPAL. (2015), Efficient Detection of Pathogenic Leptospires Using 16S Ribosomal RNA, PLOS ONE, 10(6), 128913-.
GENÇ OKTAY,BÜYÜKTANIR ÖZLEM,SERDAR GÜLNUR,YUNUS KILIÇOĞLU,OTLU SALİH. (2015), Development and validation of sandwich quantitative ELISA prototypebased on the bovine IFNg for the detection of cellular immunity, TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES, 39(), 724-729.
AÇICI MUSTAFA,BÖLÜKBAŞ CENK SONER,GÜRLER ALİ TÜMAY,UMUR ŞİNASİ,BÜYÜKTANIR ÖZLEM. (2013), Seroprevalence of Fasciolosis in equines of the Black Sea region Turkey, Journal of Equine Veterinary Science, 33(), 62-66.
Büyüktanır Ö., Akan M., Özcengiz E.. (2012), Investigation of immunogenicity and protective efficiency of Bordetella bronchiseptica fimbriae in mice, Ankara Üniv Vet Fak Derg, 59(), 95-101.
BÜYÜKTANIR ÖZLEM,GENÇ OKTAY,ÇELEBİ ÖZGÜR,YURDUSEV NEVZAT. (2012), RAPID IMMUNOFILTRATION ASSAY AS A FIELD DIAGNOSTIC TOOL FOR OVINE BRUCELLOSIS, Journal of Immunoassay and Immunochemistry, 33(1), 35-47.
GENÇ OKTAY,BÜYÜKTANIR ÖZLEM,YURDUSEV NEVZAT. (2012), Rapid immunofiltration assay based on colloidal gold protein G conjugate as an alternative screening test for bovine and ovine brucellosis, Tropical Animal Health and Production, 44(), 213-215.
Genç O, Büyüktanır Ö, Yurdusev N.. (2011), Development of an individual rapid test based on enzymatic immunofiltration assay for detection of anti Brucella abortus antibody in bovine sera, Journal of Veterinary Diagnostic Investigation, 23(), 49-56.
Büyüktanır Ö., Yağcı T., Fındık A., Yıldırım T., Yurdusev N.. (2011), Generation of Mouse Hybridomas Secreting Anti Salmonella Enteritidis Antibodies and Their Preliminary Characterization, Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 17(), 667-670.
Büyüktanır Ö., Genç O., Yurdusev N.. (2011), Production purification and characterization of the recombinant Brucella abortus rp17 Protein, Kafkas Univ Vet Fak Dergisi, 17(), 135-140.
Fındık A, Büyüktanır Ö, Yurdusev N.. (2010), LPS and flagellin based models for serological screening and confirmation of Salmonella infections in chickens, Kafkas Üniversitesi Veteriner Fakültesi Dergisi,
Terzi G., Büyüktanır Ö., Genç O., Gücükoğlu A., Yurdusev N.. (2010), Detection of Brucella antibody and DNA in cow milk by ELISA and PCR methods, Kafkas Univ Vet Fak Derg, 47-52.
Genç O., Büyüktanır Ö., Yurdusev N. 2010. (2010), Development of qualitative and quantitative ELISA models for bovine Brucellosis diagnosis, Kafkas Univ Vet Fak Derg, 16(), 287-291.
Büyüktanır Ö.. (2010), Günümüzde biyoteknolojik bakteriyel aşılar, Atatürk Üniversitesi Veteriner Bilimleri Dergisi,
BÜYÜKTANIR ÖZLEM,GENÇ OKTAY,YURDUSEV NEVZAT. (2010), Bi antigenic immunoassay models based on the recombinant PvpA proteins for Mycoplasma gallisepticum diagnosis in chickens, Journal of Veterinary Diagnostic Investigation, 22(), 908-913.
TERZİ GÖKNUR,BÜYÜKTANIR ÖZLEM,YURDUSEV NEVZAT. (2009), Detection of the tdh and trh genes in Vibrio parahaemolyticus isolates in fish and mussels from Middle Black Sea Coast of Turkey, Letters in Applied Microbiology, 16(49), 47-52.
Büyüktanır Ö, Yıldırım T, Yakıcıer C, Genç O, Yurdusev N. (2008), Recombinant PvpA Protein Based Diagnostic Prototype for Rapid Screening of Chicken Mycoplasma gallisepticum Infections, Veterinary Microbiology, 129(), 139-149.
Özcengiz E, Ünver D, Çayan HH, Büyüktanır Ö, Tepeler C.. (2005), Adsorbe tetanoz aşısı proses geliştirme ve üretim çalışmaları, Türk Mikrobiyoloji Cemiyeti Dergisi,
Büyüktanır Ö, Akan M, Özcengiz .. (2005), Değişik B bronchiseptica suşlarında virulans faktörleri ve immünojenik özellikler, Türk Mikrobiyoloji Cemiyeti Dergisi,
Özcengiz E, Kılınç K, Büyüktanır Ö, Günalp A.. (2004), Rapid purification of Pertussis Toxin PT and Filamentous Hemagglutinin FHA by Cation Exchange Chromatography, Vaccine, 22(), 1570-1575.
Borrelia burgdorferi. Methods in Molecular Biology
Yang Xiuli,Thakur Meghna,Koci Juraj,Smith Alexis A,Singh Preeti,Zhuang Xuran,Promnares Kamoltip,Wang Yan,BÜYÜKTANIR YAŞ ÖZLEM,Pal Utpal (2017), "İngilizce", Sağlık Bilimleri Temel Alanı->Tıbbi Mikrobiyoloji, Bilimsel Kitap