Academic Members

Prof.
Yasemin Gürsoy Özdemir

Nöroloji

yasemin.ozdemir@istinye.edu.tr

1968 yılında Ankara’da doğdu. Hacettepe Üniversitesi Tıp Fakültesi’nden1992 yılında mezun oldu. Aynı üniversitede Nöroloji uzmanlık eğitimini1997 yılında ve Temel Nörolojik Bilimler doktorasını 2001 yılında tamamladı. 2001-2004 yılları arasında Fulbright bursiyeri olarak doktora sonrası çalışmalarını Harvard Üniversitesi’nde sürdürdü. 2004-2014 yılları arasında akademik hayatına Hacettepe Üniversitesi Tıp Fakültesi ve Nörolojik Bilimler ve Psikiyatri Enstitüsü’nde devam etti. 2004 yılında Doçentlik ve 2011 yılında Profesörlük ünvanını aldı. 2004-2014 yılları arasında Nörobilim doktorasının yapılandırılması, araştırma laboratuvarlarının kurulması ve Nörolojik Bilimler Enstitüsü Müdür Yardımcılığı görevlerinde bulundu. 2014-2024 yılları arasında Koç Üniversitesi Tıp Fakültesi’nde çalıştı. Koç Üniversitesi’nde Nöroloji Anabilim Dalı başkanlığı, Sağlık Bilimleri Enstitüsü Müdürlüğü ve Tıp Fakültesi Dekan Yardımcılığı görevlerinde bulundu. Özdemir sinirbilim alanında özellikle migren ve inme oluş mekanizmaları ve tedavileri üzerindeçalışmalarını sürdürmektedir. Beyin kan akımı, mikrodolaşım, kan beyin bariyeri ve tüm bu yapıların nörolojik hastalıklar özellikle demans üzerine etkileri son yıllarda yoğun çalıştığı alanlardır. Bu çalışmaları Science, Nature Medicine gibi yüksek impaktlı dergilerde yayınlanmıştır. Bilim akademisi asli üyesi olarak 2024 yılında seçilmiştir. Çok sayıda Tübitak ve Tüseb proje yürütücülüğü, COST aksiyon başkan yardımcılığı vardır. Tübitak Bilim Teşvik, Eczacıbaşı Bilim Teşvik, TÜBA GEBİP, Koç Üniversitesi Araştırma ödülü gibi pek çok ödül ve bursa layık görülmüştür. YÖKAK ile çalışmalarda bulunmuş, özellikle sağlık bilimleri enstitülerinin etiket süreçlerinin oluşturulması, değerlendirme kitapları ve dökümanlarının hazırlanmasında ve YÖKAK değerlendiricisi olarak saha çalışmalarında yer almıştır.

Çalışma Alanları

Sağlık Bilimleri Temel Alanı
Nöroloji

Occipital bending in migraine with visual aura, 2021
Three-dimensional neuron-astrocyte construction on matrigel enhances establishment of functional voltage-gated sodium channels, 2021
A novel shoulder disability staging system for scapulothoracic arthrodesis in patients with facioscapulohumeral dystrophy, 2020
Isolated Hypoglossal Nerve Palsy due to a Jugular Foramen Schwannoma, 2019
Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related MRI lesions, 2018
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection, 2018
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection, 2018
A MULTIDISCIPLINARY CLINICAL APPROACH TO FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY ORTHOPEDIC SURGERY IN FACIOSCAPULOHUMERAL DYSTROPHY, 2018
A multidisciplinary clinical approach to facioscapulohumeral muscular dystrophy, 2018
Microembolism of single cortical arterioles can induce spreading depression and ischemic injury a potential trigger for migraine and related MRI lesions, 2018
Inadequate brain glycogen or sleep increases spreading depression susceptibility, 2018
Rapid Alleviation of Parkinson's Disease Symptoms via Electrostimulation of Intrinsic Auricular Muscle Zones, 2017
A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles, 2017
Behcet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger, 2017
Behçet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger, 2017
Data of indirect immunofluorescence labeling of the mouse brain sections with sera from SLE and MS patients, 2017
Nose-to-brain delivery of farnesylthiosalicylic acid loaded hybrid nanoparticles in the treatment of glioblastoma, 2017
A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles, 2017
Data of indirect immunofluorescence labeling of the mouse brain sections with sera from SLE and MS patients, 2017
Optical coherence tomography imaging of capillary reperfusion after ischemic stroke, 2016
Reversible transverse sinus collapse in a patient with idiopathic intracranial hypertension, 2016
Poloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depression, 2015
The Presence of Autoantibodies Against Vascular and Nervous Tissue in Sera from Patients with Neuro-Behcet's Disease, 2014
Systemically administered brain targeted nanoparticles transport peptides across the blood brain barrier and provide neuroprotection, 2014
Poloxamer 188 and Citicoline provide neuronal membrane integrity and protect membrane stability in Cortical Spreading Depression, 2014
Atypical Aicardi Goutieres Syndrome Is the WRN Locus a Modifier, 2014
Nöro Behçet Hastalarının Serumlarında Beyin Dokusu ve Beyin Damarlarına Karşı Otoantikor Varlığı, 2014
An aquaporin 4 antisense oligonucleotide loaded brain targeted nanoparticulate system design, 2014
Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan PLGA polymers and their PEGylated block copolymers, 2014
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy CADASIL in Two Siblings with Neuropsychiatric Symptoms, 2013
Cell death and survival mechanisms are concomitantly active in the hippocampus of patients with mesial temporal sclerosis, 2013
Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels, 2013
Plasma 3 nitrotyrosine estimates the reperfusion induced cerebrovascular stress whereas matrix metalloproteinases mainly reflect plasma activity a study in patients treated with thrombolysis or endovascular recanalization, 2012
Microvascular protection is essential for successful neuroprotection in stroke, 2012
Brain microvascular pericytes in health and disease, 2011
Thrombotic distal middle cerebral artery occlusion produced by topical FeCl3 application a novel model suitable for intravital microscopy and thrombolysis studies, 2011
Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C EBP in reperfusion injury induced ischemic rat hippocampus, 2011
Alpha synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo a study in A30P alpha synuclein transgenic mouse, 2010
Lysosomal rupture necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia, 2010
Reply to Pericyte constriction after stroke the jury is still out, 2010
Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients, 2009
A Nanomedicine Transports a Peptide Caspase 3 Inhibitor across the Blood Brain Barrier and Provides Neuroprotection, 2009
Astrocytes are More Resistant to Focal Cerebral Ischemia Than Neurons and Die by a Delayed Necrosis, 2009
Pericyte contraction induced by oxidative nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery, 2009
A new model of transient focal cerebral ischemia for inducing selective neuronal necrosis, 2009
Hydrogen peroxide induced stroke elucidation of the mechanism in vivo, 2009
VEGF protects brain against focal ischemia without increasing blood brain permeability when administered intracerebroventricularly, 2005
Apoptotic and Necrotic Death Mechanisms Are Concomitantly Activated in the Same Cell After Cerebral Ischemia, 2004
Mouse Model of Microembolic Stroke and Reperfusion, 2004
Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss A cautionary note, 2004
Laser Speckle Flowmetry for the Study of Cerebrovascular Physiology in Normal and Ischemic Mouse Cortex, 2004
Reperfusion Induced Oxidative Nitrative Injury to Neurovascular Unit After Focal Cerebral Ischemia, 2004
Cortical spreading depression activates and upregulates MMP 9, 2004
Is the Cell Death in Mesial Temporal Sclerosis Apoptotic, 2003
Persistent Defect in Transmitter Release and Synapsin Phosphorylation in Cerebral Cortex After Transient Moderate Ischemic Injury, 2002
Spleen damage in endotoxaemic mice the involvement of nitric oxide, 2001
Chronic daily administration of selegiline and EGb 761 increases brain s resistance to ischemia in mice, 2001
Altered mechanisms of motor evoked potential generation after transient focal cerebral ischemia in the rat implications for transcranial magnetic stimulation, 2000
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia, 2000
Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia, 1999
Occlusion of the MCA by an intraluminal filament may cause disturbances in the hippocampal blood flow due to anomalies of circle of Willis and filament thickness, 1999

Multiple Skleroz Patofizyolojisinde Perisitlerin Rolü,
A Novel Shoulder Disability Staging System For Scapulothoracic Arthrodesis In Patients With Facioscapulohumeral Dystrophy, 2017
The effect of coating materials on morphology and function of the cells in two and three-dimensional primary neuronal cultures,
THE BIODISTRIBUTION OF FARNESYLTHIOSALICYLIC ACIDINCORPORATED HYBRID NANOPARTICLES FOLLOWINGINTRANASAL ADMINISTRATION IN RATS, 2017

Nanotechnology Methods for Neurological Diseases and Brain Tumor, ISBN: 9780128037966, 2017
Geriatri ve Gerontoloji, ISBN: , 2006
İç Hastalıkları, ISBN: , 2008
Akut İskemik İnme, ISBN: , 2001
Methods in Enzimology NANOMEDICINE CANCER DIABETES AND CARDIOVASCULAR CENTRAL NERVOUS SYSTEM PULMONARY AND INFLAMMATORY DISEASES, ISBN: 978-0-12-391860-4, 2012