Faculty of Medicine

Academic Members

Prof. Binnur  Şimşek

Prof.
Binnur Şimşek

Gastroenteroloji (İç Hastalıkları)

İstanbul Üniversitesi İstanbul Tıp Fakültesi’nden mezun olan Doç. Dr. Binnur Pınarbaşı Şimşek, İç Hastalıkları Anabilim Dalı ihtisasını ve Gastroenterohepatoloji Bilim Dalı yan dal ihtisasını aynı üniversitede tamamladı. 2012 yılında Gastroenteroloji doçenti ünvanını aldı. Çalışma süreci boyunca dört adet uluslararası çok merkezli çalışmada yardımcı araştırmacı olarak görev yaptı. Aynı süreçte Gastroenterohepatoloji bilim dalı karaciğer transplantasyon polikliniğinin yürütülmesinde aktif görev aldı. Başlıca ilgi alanları arasında akut ve kronik karaciğer hastalıkları (karaciğer sirozu ve komplikasyonları, varis kanamaları, akut karaciğer yetersizliği, kronik viral hepatitler, metabolik karaciğer hastalıkları, genetik geçişli karaciğer hastalıkları), yağlı karaciğer hastalığı, alkole bağlı karaciğer hastalıkları, gastrointestinal sistem kanamaları, üst sindirim sisteminin asit-peptik hastalıkları (ülser, reflü, gastrit), gluten enteropatisi ve diğer malabsorbsiyon sendromları, inflamatuvar barsak hastalıkları (ülseratif kolit ve Crohn hastalığı) yer almaktadır. Uluslararası dergilerde yayımlanmış 43 adet makale - 30 adet sözlü bildiri, ulusal dergilerde yayımlanmış 20 adet makale- 100’ün üzerinde sözlü ve poster bildiri, bir kitap bölümü çevirisi, klinik çalışmalar alanında ulusal kongrelerde alınmış toplam 6 adet ödülü (iki adet birincilik, üç adet üçüncülük ve bir adet mansiyon olmak üzere) bulunmaktadır. Gastroenterohepatoloji alanındaki ulusal ve uluslararası dergilerde makale editörlüğü görevi yapmaktadır. Türk Karaciğer Araştırmaları Derneği, Türk Gastroenteroloji Derneği, İnflamatuvar Barsak Hastalıkları Derneği ve İç Hastalıkları Uzmanlık Derneği üyesidir. Halen Liv Hospital Gastroenterohepatoloji Kliniği’nde çalışmakta olup, 2016 yılı başından beri İstinye Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı Öğretim Üyesi görevini yürütmektedir.

Araştırma Alanları

  • Lıver Cirrhosis and Portal Hypertension, Hepatoselluler carcinoma, Liver Transplantation, Viral Hepatititis, Alcoholic Liver Disease, Non -alcoholic Fatty Liver Diseas, Peptic Ulcer, Gastrointestinal Bleeding, Functional Gastrointestinal Disease, Inflammatory Bowel Disease, Malabsorbtion Syndrom, Malignant Disease of Gastrointestinal System, Videocapsule Endoscopy, Fibroscan

Çalışma Alanları

  • Sağlık Bilimleri Temel Alanı
  • Gastroenteroloji (İç Hastalıkları)
  • The Effect of Laparoscopic Sleeve Gastrectomy on Nonalcoholic Fatty Liver Disease, 2019
  • Cryptogenic liver cirrhosis and hepatitis E virus (HEV): Are they related?, 2019
  • Hepatitis B core‐related antigen monitoring during peginterferon alfa treatment for HBeAg‐negative chronic hepatitis B, 2019
  • Correlation of Hepatitis B Virus Surface Antigen Titer with Hepatitis Delta Virus Replication Level and Histological Activity in Chronic Delta Hepatitis, 2018
  • Which drugs are risk factors for the development of gastroesophageal reflux disease?, 2017
  • Gastroesophageal reflux disease and the relationship with Helicobacter pylori., 2017
  • Extracolonic findings of CT colonography: Our experience in 227 cases, 2017
  • Sağlıklı Erişkinde Akut Sitomegalovirus Hastalığı., 2016
  • Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels, 2016
  • Retention during capsule endoscopy: Is it a real problem in routine practice?, 2016
  • What is the impact of capsule endoscopy in the long term period?, 2016
  • Gastroesophageal reflux in asymptomatic obese subjects: An esophageal impedance-pH study, 2015
  • Cyclosporine Therapy As a Rescue Treatment in Acute Severe Ulcerative Colitis: A Real Life-Data From a Tertiary Center, 2015
  • ROLE OF THE TACROLIMUS IN POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME, 2015
  • Infliximab in inflammatory bowel disease: attetion to adverse events., 2014
  • Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method, 2014
  • Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey, 2013
  • Durability of Sustained Virologic Response in Chronic Hepatitis C, 2013
  • Measurement of the coronary flow velocity reserve in patients with non-alcoholic fatty liver disease., 2012
  • Long-term follow-up of hepatitis B e antigen-negative patients treated with peginterferon α-2a: progressive decrease in hepatitis B surface antigen in responders., 2012
  • The clinical significance of JAK2V617F mutation for Philadelphia-negative chronic myeloproliferative neoplasms in patients with splanchnic vein thrombosis., 2012
  • Büyüme hormonu yetersizliği olan hastalarda erken aterosklerotik değişiklikler., 2011
  • Anticoagulant therapy and Budd-Chiari syndrome: is it successful?, 2011
  • Effect of Proton Pump Inhibitor (PPI) Treatment in Obstructive Sleep Apnea Syndrome: An Esophageal Impedance-pHmetry Study, 2011
  • Second-Line Levofloxacin-Based Triple Therapy's Efficiency for Helicobacter pylori Eradication in Patients With Peptic Ulcer, 2011
  • Postprandial platelet-poor plasma 5-hydroxytryptamine concentrations during diarrhea and constipation periods of alternatingtype irritable bowel syndrome patients., 2011
  • ANTIVIRAL RESISTANCE IN NAIVE GENOTYPE D CHRONIC HEPATITIS B PATIENTS BY ULTRA-DEEP PYROSEQUENCING, 2011
  • A Randomized Trial of Peginterferon α-2a With or Without Ribavirin for HBeAg-Negative Chronic Hepatitis B, 2010
  • Is portal hypertensive enteropathy an important additional cause of blood loss in portal hypertensive patients?, 2010
  • The need for blood products in patients with crush syndrome., 2010
  • Decreased Prohepcidin Levels in Patients with HBV-Related Liver Disease: Relation with Ferritin Levels, 2010
  • PRECORE/CORE PROMOTER MUTATIONS BY ULTRA-DEEP PYROSEQUENCING IN GENOTYPE D CHRONIC HEPATITIS B NAIVE PATIENTS, 2010
  • SERUM HBSAG LEVELS DECREASE THROUGH LONG-TERM FOLLOW-UP IN HBEAG-NEGATIVE PATIENTS ACHIEVING A SUSTAINED RESPONSE TO PEGINTERFERON ALFA-2A, 2010
  • The treatment of acute liver failure with fractionated plasma separation and adsorption system: Experience in 85 applications, 2010
  • Electron microscopic findings in non-alcoholic fatty liver disease: Is there a difference between hepatosteatosis and steatohepatitis?, 2010
  • The quality of life in hemodialysis patients with chronic hepatitis C virus infection., 2009
  • Congenital Portal Vein Aneurysm Associated with Peliosis Hepatis and Intestinal Lymphangiectasia, 2009
  • Mucosa-associated lymphoid tissue lymphoma of the duodenum together with multiple intra-abdominal thromboses and hepatitis C virus infection: a case report, 2009
  • Prevalence and virological features of occult hepatitis B virus infection in female sex workers who work uncontrolled in Turkey, 2009
  • A short course of add-on adefovir dipivoxil treatment in lamivudine-resistant chronic hepatitis B patients, 2009
  • Are Acquired Hepatocerebral Degeneration and Hepatic Myelopathy Reversible?, 2009
  • Wireless Endoscopy Capsule Remaining Safely for a Long Time, 2008
  • Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey., 2008
  • Pyoderma gangrenosum treated with infliximab in inactive ulcerative colitis, 2008
  • A rare cause of hemosuccus pancreaticus: primary splenic artery aneurysm ruptured into pancreatic serous cystadenoma., 2008
  • A rapidly increasing abdominal girth in a young patient: MDCT findings of Budd-Chiari syndrome, 2008
  • The presence of HCVRNA in the peripheral blood mononuclear cells of the individuals with isolated anti HCV positivity: Is HCV hiding out?, 2008
  • Response to Hepatitis B Vaccination in Patients with Celiac Disease, 2008
  • Kriptojenik karaciğer sirozu – pernisyöz anemi birlikteliği., 2007
  • A case of Aeromonas hydrophila enteritis in the course of ulcerative colitis., 2007
  • Eosinophilic esophagitis: case report., 2007
  • Somatostatin and propranolol to treat small-for-size syndrome that occurred despite splenic artery ligation, 2007
  • Merkel-Cell Carcinoma Arising After Liver Transplantation: A Case Report, 2005
  • Peritoneal amyloidosis caused by Familial Mediterranean Fever., 2005
  • Virological breakthrough is not a detrimental phenomenon in patients with compensated cirrhosis: Results of a long term lamivudine therapy, 2005
  • Gezici dalak: infarktüs gelişen ve esansiyel trombositemiyi taklit eden bir olgu., 2004
  • Liver abscess as a rare complication of Crohn's disease: a case report., 2004
  • Ulcerative colitis: Analyses of 116 cases (do extraintestinal manifestations effect the time to catch remission?), 2004
  • Endothelial dysfunction in renal transplant patients is closely related to serum cyclosporine levels, 2004
  • Böbrek yetersizliği ile ortaya çıkan multipl paraproteinemiye rastlanan fatal seyirli bir miyeloma olgusu, 2003
  • Miyokard infarktüsünde trombolitik tedaviyi takiben gelişen intraalveoler hemoraji olgusu, 2003
  • Bir olgu nedeniyle miksödem komasına yeniden bakış., 2003
  • Clinical outcome of Crohn's disease treated with infliximab., 2003
  • Alport sendromunun bir varyantı: Epstein Sendromu., 2002
  • Renal transplantasyonlu hastalarda QT dispersiyonunun önemi., 2002
  • Bir olgu nedeniyle antiglomerül bazal membran hastalığı., 2000
  • Pyoderma gangrenosum treated with infliximab in inactive ulcerative colitis., 2008
  • Neutrophilic Eccrine Hidradenitis Developed During Acute Myeloid Leukemia Therapy:A Case Report, 2014
  • Cyclosporine theraphy as a rescue treatment in acute severe ulcerative colitis: A real life-data from a tertiary center, 2015
  • HBsAg clearence after long term follow-up in chronic hepatitis B patients treated with interferon alpha and nucleos(t)ide analoges., 2009
  • Effect of PPI treatment in sleerp apnea syndrome: an esophageal impadance –PH study, 2009
  • Endothelial dysfunction in renal amylodosis., 2007
  • Measurement of coronary flow velocity reserve in patients with non-alcoholic fatty liver disease., 2009
  • Is osteoprosis an extraintestinal manifestation of inflammatory bowel disease?, 2009
  • Giant peritoneal cyst hidatic and albendazol induced aplastic anemia in noncirrhotic portal hypertensive patient caused by paroxismal nocturnal hemoglobinuria., 2009
  • What is the cause of iron overload in HBV related chronic liver disease: decreased hepcidin levels?, 2009
  • Measurement of coronary flow velocity reserve in patients with non-alcoholic fatty liver disease., 2009
  • Azathioprine toxicity in inflammatory bowel disease., 2008
  • Acute hepatitic attack on chronic liver disesase., 2008
  • Lamivudine treatment for acute severe or fulminant hepatitis B: Single center experience., 2008
  • The presence of HCV RNA in peripheral blood mononuclear cells of the individuals with isolated anti-HCV positivity: is HCV hiding out?, 2008
  • MEFV gene mutations and inflammatory bowel disease: Is tehere any effect?, 2008
  • What did change in Turkey?, 2008
  • What is the cause of obscure bleeding in portal hypertensive patients?, 2008
  • Eosinophilic esophagitis, 2007
  • Occult hepatitis B infection in female prostitutes: Is it a risk factor for public health?, 2007
  • Clinical features of primary sclerosing cholangitis (PSC) in Turkey: Low prevalence of ulcerative colitis (UC)., 2006
  • Response to hepatitis B vaccination in patients with celiac disease., 2006
  • Virological breakthrough is not a detrimental phenomenon in patients with compensated cirrhosis: results of a long term lamivudine therapy., 2005
  • Extraintestinal manifestations in Crohn’s disease and ulcerative colıitis., 2004
  • Elevated aminotransferase levels in celiac disease., 2004
  • 11.1 5-7 Haziran 2005 5. Ulusal Hepatoloji Kongresi’nde sunulan ‘’Spontan Asit Enfeksiyonu Tanısında İdrar Stripi İle Lökosit Esteraz Aktivitesi Tayini’’ adlı çalışma sözlü bildiri üçüncülük ödülü , 2005
  • 11.2 4-7 Kasım 2006, 3. Gastroenteroloji Araştırma Proje Destek Ödülü 2006 Yarışması ‘’Mansiyon Ödülü’’ , 2006
  • 11.3 07-10 Haziran 2007 6. Ulusal Hepatoloji Kongresi’nde sunulan ‘’İzole Anti HCV Pozitif Bireylerde Periferik Kan Mononükleer Hücrelerinde HCV-RNA Varlığı: HCV Saklanıyor mu?’’ adlı çalışma sözlü bildiri dalında üçüncülük ödülü , 2017
  • 11.4 12-16 Kasım 2008 25. Ulusal Gastroenteroloji Haftası’nda sunulan ‘’Türkiye’de Gastroözofagial Reflü Hastalarında Endoskopik Bulgular: Çok Merkezli Prospektif Çalışma’’ adlı çalışma sözlü bildiri dalında birincilik ödülü, 2017
  • 11.5 4-7 Kasım 2006 23. Ulusal Gastroenteroloji Haftası’nda sunulan ‘’Üst GİS semptomu ile başvuran hastalarda malignite sıklığı; tümör tarama yaşı ne olmalıdır?’’ adlı çalışma poster bildiri dalında üçüncülük ödülü, 2008
  • 11.6 01-05 Haziran 2011 8. Ulusal Hepatoloji Kongresi’nde sunulan ‘’Karaciğer nakilli hastalarda geç dönemde kronik böbrek yetersizliği: Prevelans ve risk faktörleri’’ alı çalışma poster bildiri dalında birincilik ödülü , 2011